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DATE: 2015
CITATION:
Olkkola S, Kovanen S, Roine J, Hänninen ML, Hielm-Björkman A, Kivistö R. Population Genetics and Antimicrobial Susceptibility of Canine Campylobacter Isolates Collected before and after a Raw Feeding Experiment. PLoS One. 2015 Jul 14;10(7):e0132660.
LINK: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501809/ ABSTRACT:
In recent years, increasing numbers of consumers have become interested in feeding raw food for their pet dogs as opposed to commercial dry food, in the belief of health advantages. However, raw meat and internal organs, possibly contaminated by pathogens such asCampylobacterspp., may pose a risk of transmission of zoonoses to the pet owners.Campylobacter jejuniis the leading cause of bacterial gastroenteritis in humans butC.upsaliensishas also been associated with human disease. In this study we investigated the effect of different feeding strategies on the prevalence ofCampylobacterspp. in Finnish dogs. We further characterized the isolates using multilocus sequence typing (MLST), whole-genome (wg) MLST and antimicrobial susceptibility testing. Dogs were sampled before and after a feeding period consisting of commercial raw feed or dry pellet feed. Altogether 56% (20/36) of the dogs yielded at least oneCampylobacter-positive fecal sample.C.upsaliensiswas the major species detected from 39% of the dogs before and 30% after the feeding period. TwoC.jejuniisolates were recovered, both from raw-fed dogs after the dietary regimen. The isolates represented the same genotype (ST-1326), suggesting a common infection source. However, no statistically significant correlation was found between the feeding strategies andCampylobacterspp. carriage. The global genealogy of MLST types of dog and humanC.upsaliensisisolates revealed weakly clonal population structure as most STs were widely dispersed. Major antimicrobial resistance amongC.upsaliensisisolates was against streptomycin (STR MIC > 4mg/l). Apart from that, all isolates were highly susceptible against the antimicrobials tested. Mutations were found in the genesrpsLorrpsLandrsmGin streptomycin resistant isolates. In conclusion, increasing trend to feed dogs with raw meat warrants more studies to evaluate the risk associated with raw feeding of pets in transmission of zoonoses to humans.
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